For more than 20 years, the Gene Transcription in Yeast meeting series biannually brings together researchers using yeast to study mechanisms of gene expression. Owing to the exceptional experimental accessibility of yeasts - in vivo and in vitro, in S. cerevisiae, S. pombe and other yeasts - the yeast community keeps generating both pioneering method development as well as new concepts that often inspired analogous discoveries in the metazoan/human system. The meeting traditionally covers all steps from chromatin to transcription to RNA processing, and integrates different approaches such as structural biology, biochemistry, genetics, cell biology, high-throughput, computational, systems and single-cell technologies. While this groundwork is maintained, there is also a special focus for each meeting. The subtitle “From single molecules to phase separation” reflects both a renewed attention to the individual molecule as well as the will to embrace the exciting discoveries on liquid-liquid phase separation (LLPS) mediating the compartmentalization of many cellular, including nuclear functions. Invited speakers will talk about the discovery, function and biophysics of LLPS and the intrinsically disordered proteins involved in their formation. They will cover single molecule analyses including structural studies and systems biology will bring a quantitative flavor to the many genome-wide studies also dealing with the co-existence of concurrent machineries (e.g. replication) on the DNA. Importantly, talks selected from submitted abstracts and posters presented in prominent and extensive sessions contribute a wealth of cutting-edge research from the vibrant yeast community.
About the meeting
Image courtesy of:
Tineke Lenstra: movie of transcription factor binding (red) to a transcription site (green);
Geeta Narlikar: Swi6-chromatin droplet (Designed by Serena Sanulli and drawn by @drawinscience)
Alex Holehouse: Structure of Gcn4 DNA binding and transactivation domains
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This meeting does a fantastic job covering all the different levels of transcription and gene expression studies: single molecule microscopy, structural biology, genomics, system biology, and many others. Yeast is unique in that all of these approaches can be used and integrated in a way that is simply impossible in mammalian cells, even in this age of CRISPR.
One of the most interesting meetings
This meeting had an especially well-balanced blend of topics ranging from the chromatin template to all levels of RNA biology, i.e., transcription, RNA processing, RNA export, and RNA degradation.
It was a formidable conference covering the hottest topics of the field.
Plenty of non published data
I was very impressed that most people presented unpublished data.
I took 30 pages of notes during the meeting. Just today during the departmental seminar of myhome institution, I gave a short meeting report and could not even remotely cover all the new and relevant information. The majority of presentations covered so far unpublished data.
Plenty of new information and mehtods.
The conference was extremely enriching, presenting the new advances in the field, for many of them ahead of publication (many papers available in BioRxiv before publication in journal).
Poster session was excellent. Organizer provide us full opportunity and time to explain our research to other researchers. Time we spends with researchers was excellent
Great organization and plenty of time to see posters and talk with the scientis
The scientific quality of the posters was mainly very high. It was great to have posters related to the oral presentations. So we could follow up on topics that were raised already and got further Information. It was very good that poster sessions were in the evening with an “open end”.
There was ample time for discussions and meeting all the participants. Indeed, the attendance to the poster sessions was very high. PhD students were excited to discuss their projects with other PIs, and PIs got into more detailed discussions than was possible during the questions after the talk.
This is excellent for research. We met many young researchers and discuss the research and possibilities of future project collaborations.
At the previous workshop in 2016, I made a new contact and we started a collaboration. I presented results from this collaboration in my lecture and discussed ongoing experiments with him. This very interesting project would not have started if we had not met at the last workshop. At the latest workshop I again made a new contact who has proposed a collaboration.
My lab is just going into a new direction involving R-Loops and at the meeting I could talk at length with two of the well-known experts in this field right away. We are still in contact and the first plasmid that we need in this regard is already underway by FedEx. The community at this meeting is extremely helpful. People are very accessible and as everyone works with the same model system, the exchange of reagents and protocols is excellent and fast.
This workshop is excellent to meet new people. The combination of venue and program “forces” people to interact
Many collaborations set up and critical info gained for ongoing challenging approaches
Thanks to this meeting i was able to find a eventual lab for my post doc.
Probably the most useful part of this meeting is the networking
Awesome Place. I want to attend same conference if it will schedule in future
Excellent location with just enough isolation from the surroundings to keep everyone nearby and foster a sense of community.
The location is delightful, the accommodation and food were excellent (the weather was not, but that didn’t matter). Access to the hotel was problematic due to extensive construction works but that is temporary.
The conference room was perfect. We never had to wait for meals or coffee. The rooms were very good.
Very nice venue, with the hotel and the lecture hall at the same location. This means that there is no time wasted on traveling to and from the venue and therefore much more time to talk /discuss with others.
The location was spectacular – a bit isolated but in a good way to balance both work and relaxation during down time
Ideal place as all speakers are accessible in the venue and do not leave. That is key to start new interactions.
The atmosphere of this place is amazing, it is very easy to get contact with differentpeople (PhD-students, post-docs, PIs).